Related Experiment Video
Updated: May 22, 2026
09:28
Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
[Urological cancers: ECCO/ESMO congress 2011]
Nabil Ismaili1, Said Afqir, Rhizlane Belbaraka
1Centre régional d'oncologie, hôpital Hassan II, département d'oncologie médicale, Agadir 80000, Maroc. ismailinabil@yahoo.fr
Presse Medicale (Paris, France : 1983)
|May 29, 2012
Summary
Innovative treatments for prostate cancer, including abiraterone acetate and sipuleucel-T, were presented. Research also highlighted genetic polymorphisms predicting anti-angiogenic efficacy in renal clear cell carcinoma.
Area of Science:
- Oncology
- Urology
Background:
- The European Cancer Organisation (ECCO)/European Society for Medical Oncology (ESMO) congress in Stockholm (September 2011) focused on advancements in urological cancer research.
- Key updates aimed to revolutionize patient management strategies for various urological malignancies.
Framework:
- Prostate Cancer: Abiraterone acetate recommended for post-docetaxel patients; sipuleucel-T for asymptomatic/minimally symptomatic castrate-resistant prostate cancer.
- Bone Metastases: Alpharadine suggested for symptomatic bone metastases; denosumab for high-risk non-metastatic prostate cancer patients.
- Renal Cell Carcinoma: Genetic polymorphisms identified as predictive biomarkers for anti-angiogenic agent efficacy.
Implementation:
- Dual targeting of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) pathways shows significant promise in metastatic renal clear cell carcinoma.
- Belinostat and bortezomib emerged as promising therapeutic agents for urothelial cancer.
Implications:
- These findings represent significant progress in urological cancer treatment, offering new therapeutic avenues and personalized medicine approaches.
- Further research and clinical trials are anticipated to validate and implement these innovative strategies for improved patient outcomes.
Related Concept Videos
01:28Urologic Endoscopic Procedure: Cystoscopic Examination
Meaning of Cystoscopic Examination:Cystoscopy is an essential diagnostic tool in urology that is used to assess the structure and function of the genitourinary system. It provides a direct view of the urethra, bladder, and, in some cases, the ureteral openings. This procedure helps detect structural abnormalities, infections, cancers, and blockages in the urinary tract. There are two types of cystoscopy:Flexible cystoscopy is commonly performed in outpatient settings due to its less invasive...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:18Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...