[Brown's syndrome]
M D'Esposito1, E Chiosi, P Aurilia
1Clinique ophtalmologique, Faculté de Médecine et de Chirurgie de l'Université de Naples, Italie.
Ophtalmologie : Organe De La Societe Francaise D'Ophtalmologie
|July 1, 1990
Summary
This study addresses Brown's syndrome, a condition causing eye movement obstruction. Surgical correction involving partial trochleotomy and adhesion lysis was explored, with findings demonstrated using an eye motion simulator.
Area of Science:
- Ophthalmology
- Surgical Techniques
- Biomechanics
Context:
- Brown's syndrome involves trochlear obstruction affecting eye movement.
- Observed tight adhesions or thickening of the superior oblique tendon posterior to the trochlea in operated patients.
- Previous surgical interventions may lead to these abnormalities.
Purpose:
- To describe a surgical technique for correcting Brown's syndrome.
- To investigate the morphological basis of trochlear obstruction in Brown's syndrome.
- To experimentally demonstrate the mechanism of obstruction using an eye motion simulator.
Summary:
- A surgical approach involving partial trochleotomy, lysis of adhesions, and Scott-Knapp sutures was employed.
- The study experimentally validated the obstructive nature of the trochlea in Brown's syndrome.
- Morphological findings included tight adhesions or increased tendon thickness posterior to the trochlea.
Impact:
- Provides a potential surgical solution for Brown's syndrome.
- Enhances understanding of the biomechanical factors contributing to Brown's syndrome.
- Offers a method for experimental validation of ocular motility disorders.
More Related Videos
Related Concept Videos
01:11Genetic Lingo
Overview
01:39Epistasis
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
01:33Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:19Cushing Syndrome II: Pathophysiology
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...