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Related Experiment Videos

Adrenal-testis interaction in the stallion.

J E Cox, N M Jawad

    Equine Veterinary Journal
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Synthetic adrenocorticotrophin and cortisol initially increase stallion testosterone but repeated doses lower it. After stopping treatment, testosterone levels rebound higher than before.

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    Area of Science:

    • Veterinary Endocrinology
    • Reproductive Physiology in Equines

    Background:

    • Adrenocorticotrophin and cortisol are key hormones influencing reproductive function.
    • Understanding their impact on testosterone is crucial for equine health.

    Purpose of the Study:

    • To investigate the short- and long-term effects of synthetic adrenocorticotrophin and cortisol on peripheral plasma testosterone in stallions.
    • To analyze the hormonal response following treatment cessation.

    Main Methods:

    • Administration of synthetic adrenocorticotrophin and cortisol to 2 stallions.
    • Measurement of peripheral plasma testosterone concentrations before, during, and after treatment.
    • Evaluation of acute and chronic hormonal changes.

    Main Results:

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    • A single injection of either hormone caused a temporary increase in plasma testosterone.
    • Repeated injections (twice daily for 5 days) led to a depression in plasma testosterone concentrations.
    • Cessation of treatment resulted in a subsequent rise in plasma testosterone above pretreatment levels.

    Conclusions:

    • Both short-term and long-term administration of adrenocorticotrophin and cortisol significantly alter testosterone levels in stallions.
    • The observed rebound effect suggests a complex regulatory mechanism of the hypothalamic-pituitary-gonadal axis in equines.