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Updated: May 22, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
Group cognitive-behavioral therapy for clients with major depression in residential substance abuse treatment
Katherine E Watkins1, Sarah Hunter, Kimberly Hepner
1RAND Corporation, 1776 Main St., Santa Monica, CA 90407, USA. kwatkins@rand.org
Objective:
The BRIGHT (Building Recovery by Improving Goals, Habits, and Thoughts) study was a community-based effectiveness trial that compared residential substance abuse treatment with residential treatment plus group cognitive-behavioral therapy (CBT)for depression. This brief report focuses on the subgroup of participants with major depression.
Methods:
The authors used a quasi-experimental design and an intent-to-treat analysis. Out of 299 participants enrolled, 135 had major depression. Primary outcomes were change in depression symptoms, mental health functioning, and days of alcohol use and problematic substance use.
Results:
At the three-month follow-up, participants with major depression reported less severe depression and better functioning, compared with participants with major depression who received usual care. At six months, functioning continued to be higher and problem substance use was lower.
Conclusions:
Group CBT was an effective treatment for major depression for clients in residential substance abuse treatment. These results extend the effectiveness of group CBT for major depression to a new setting, patient population, and type of provider.
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