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Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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Related Experiment Video

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Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue
06:14

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Published on: May 8, 2018

Nanotechnology for neurodegenerative disorders.

Francesca Re1, Maria Gregori, Massimo Masserini

  • 1Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy. francesca.re1@unimib.it

Nanomedicine : Nanotechnology, Biology, and Medicine
|May 30, 2012
PubMed
Summary

Nanomaterials offer solutions for delivering drugs and imaging agents to the brain, overcoming the blood-brain barrier challenge for neurodegenerative diseases. This review explores their therapeutic and diagnostic potential, alongside neuroprotection and regeneration strategies.

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Last Updated: May 22, 2026

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Published on: May 8, 2018

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High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Neuroscience

Background:

  • Drug and imaging agent delivery to target sites is crucial for treating various disorders.
  • The blood-brain barrier poses a significant challenge for brain targeting in treating neurodegenerative diseases.
  • Engineered nanomaterials offer potential solutions due to their size, properties, and multi-functionalization capabilities.

Purpose of the Study:

  • To review the current state of nanomaterials for diagnosing and treating neurodegenerative disorders.
  • To explore nanomaterials for neuroprotection and neuronal tissue regeneration.
  • To discuss the potential neurotoxicity of nanomaterials and future nanotechnological approaches.

Main Methods:

  • Review of existing literature on nanomaterials for neurological applications.
  • Analysis of nanomaterial properties relevant to crossing the blood-brain barrier.
  • Discussion of therapeutic, diagnostic, and regenerative applications of nanomaterials in neurodegenerative diseases.

Main Results:

  • Nanomaterials can be engineered to cross the blood-brain barrier, enabling targeted delivery.
  • They show promise for diagnostic imaging, drug delivery, neuroprotection, and tissue regeneration in neurodegenerative diseases.
  • Potential neurotoxicity of nanomaterials requires careful consideration and further investigation.

Conclusions:

  • Nanomaterials represent a promising frontier in addressing the challenges of brain targeting for neurodegenerative diseases.
  • Multi-functionalized nanomaterials offer versatile applications in therapy, diagnostics, and regenerative medicine.
  • Further research is needed to optimize nanomaterial design, assess safety, and translate these findings into clinical practice.