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[Estrogen receptors beta--new target in cellular lung cancer treatment]

M I Davydov, T A Bogush, B E Polotskiĭ

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |May 31, 2012
    PubMed

    Insights

    Estrogen receptor beta (ERbeta) is increasingly expressed in lung adenocarcinoma, suggesting tamoxifen may be a viable treatment. This research explores ERbeta

    Area of Science:

    • Oncology
    • Endocrinology
    • Molecular Biology

    Context:

    • Estrogen receptors (ERs), specifically ER-alpha and ER-beta, play a role in cellular lung cancer.
    • Estrogen and antiestrogen effects on lung tumor development and progression in humans and animals are under investigation.
    • Ambiguity exists regarding the frequency of ER-beta expression in lung cancer cells.

    Purpose:

    • To review the expression of ER-alpha and ER-beta in lung cancer cells.
    • To analyze the role of ERs in estrogen and antiestrogen effects on lung cancer.
    • To investigate the reasons for inconsistent data on ER-beta expression frequency.
    • To quantitatively assess ER-beta expression in lung cancer patients' tumor tissues.
    • To propose a new therapeutic strategy for lung cancer using antiestrogens.

    Summary:

    • A literature review examined estrogen receptor (ER) expression (ER-alpha and ER-beta) in lung cancer.
    • Authors quantitatively assessed ER-beta expression in 79 males and 22 females with lung adenocarcinoma.
    • Increased ER-beta expression and incidence of high ER-beta tumors were observed in lung adenocarcinoma, irrespective of gender or smoking status.

    Impact:

    • Findings suggest a potential therapeutic strategy using antiestrogens like tamoxifen for lung cancer.
    • Adjuvant tamoxifen therapy may benefit patients with ER-beta-positive lung cancer, similar to breast cancer treatment.
    • This research could lead to novel treatment approaches for lung adenocarcinoma.

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