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[VEGF in neoplastic angiogenesis]

V P Chekhonin, S A Shein, A A Korchagina

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |May 31, 2012
    PubMed

    Insights

    Vascular Endothelium Growth Factor (VEGF) drives tumor growth. Inhibiting VEGF restricts tumor vascularization and progression, but resistance limits complete recovery in cancer patients.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Research

    Context:

    • Solid tumor progression is critically dependent on tumor vascularization and angiogenesis.
    • Vascular Endothelium Growth Factor (VEGF) is a key regulator of angiogenesis.
    • Antiangiogenic therapies targeting VEGF have shown promise in various cancers.

    Purpose:

    • To review the role of VEGF in tumor progression and the efficacy of antiangiogenic therapies.
    • To discuss the mechanisms of resistance to antiangiogenic treatment.

    Summary:

    • VEGF is essential for the development of new blood vessels in tumors, supporting their growth and metastasis.
    • Inhibition of VEGF, exemplified by bevacizumab, can lead to regression of tumor vessels and restrict tumor growth.
    • Clinical applications include breast cancer, colorectal cancer, and gliomas.

    Impact:

    • Antiangiogenic therapy provides a valuable strategy for cancer treatment, primarily by restricting tumor growth.
    • Understanding resistance mechanisms is crucial for improving the long-term effectiveness of antiangiogenic therapies.
    • Further research into overcoming resistance pathways is necessary for achieving complete tumor eradication.

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