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Updated: May 21, 2026

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
Published on: June 14, 2014
[The process of X inactivation in the mouse]
Lucie Delaroche1, Pauline Demailly, Katia Ancelin
1Faculté de médecine, université Paris Diderot, Paris, France. lucie.delaroche@bch.aphp.fr
Abstract:
X chromosome inactivation (XCI) is an excellent model for studying how epigenetic marks are initiated during early embryogenesis. XCI is an essential process that takes place in females, leading to dosage compensation between males and females. In mouse, it occurs in two waves: the first one is paternally imprinted, during the preimplantation period and the second one occurs in a random fashion. We provide here an update of the main molecular steps and hypothesis underlining this complex process.
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