Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Drug Toxicity: Risk factors

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...

Pharmaceutical Poisoning: Treatment Strategies

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Lethal Alleles

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-risk human papillomavirus prevalence and factors associated with testing positive in women living in Montserrat.

PLOS global public health·2026

Same author

Dental Rehabilitation of the Scapular Tip in Maxillary Reconstruction.

Head & neck·2026

Same author

Trends in lumbar puncture utilization across a health system and in emergency department practice.

The American journal of emergency medicine·2026

Same author

The Current Cardio-Oncology Landscape Across Australia.

Current treatment options in oncology·2026

Same author

Assessment of compact cylindrical and plane-parallel ionization chambers as reference dosimeters in high-energy photon beams.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026

Same author

The Effect of Preoperative Tranexamic Acid on Blood Transfusions in Geriatric Hip Fracture Surgery: A Randomized Controlled Trial.

Journal of orthopaedic trauma·2026

Same journal

Learning Surgery's Moral Questions: Mentorship, Reflection, and Professional Formation.

The American surgeon·2026

Same journal

Complete Response of Merkel Cell Carcinoma to Immunotherapy and Single-Fraction Radiotherapy Following Severe COVID-19 Infection: A Case Report and Review of Immune Mechanism.

The American surgeon·2026

Same journal

Perioperative Acute Myocardial Infarction in Non-Cardiac Operations: A National Analysis.

The American surgeon·2026

Same journal

Outcomes of Completion Cholecystectomy: Association With Patient Comorbidity in a National Database.

The American surgeon·2026

Same journal

Building the Conversation: Editorial Stewardship in Contemporary Surgical Publishing.

The American surgeon·2026

Same journal

Musculoskeletal Pain in Surgeons on Operating Days.

The American surgeon·2026

See all related articles

Search research articles

Related Experiment Videos

Old and undertriaged: a lethal combination.

Amelia Rogers¹, Frederick Rogers, Eric Bradburn

¹Lancaster General Hospital, Lancaster, Pennsylvania, USA.

The American Surgeon

|May 31, 2012

Summary

This summary is machine-generated.

Elderly trauma patients undertriaged (UT) face a higher risk of death. Current trauma activation criteria may fail to identify high-risk older adults, necessitating improved geriatric trauma triage guidelines.

Related Experiment Videos

Area of Science:

Geriatric Trauma Surgery
Emergency Medicine
Trauma Systems Evaluation

Background:

Geriatric trauma patients present unique challenges including occult injuries and hypoperfusion.
Elderly patients often have comorbidities that complicate assessment and increase risk.
Current trauma activation systems may not adequately identify all high-risk elderly individuals.

Purpose of the Study:

To investigate the outcomes of undertriaged (UT) elderly trauma patients.
To determine if undertriage is associated with increased mortality in geriatric trauma.
To identify factors contributing to undertriage in the emergency department.

Main Methods:

Retrospective analysis of elderly patients (age ≥ 65) admitted to the trauma service from 2000-2010.
Defined undertriaged (UT) patients as those with Injury Severity Score (ISS) > 15 who did not undergo trauma team activation.
Utilized univariate and multivariate analysis to examine factors contributing to UT and patient outcomes.

Main Results:

A total of 4534 elderly patients were analyzed, with 15.1% identified as UT.
Undertriaged elderly patients demonstrated a significantly higher likelihood of mortality.
This increased risk of death persisted after adjusting for Revised Trauma Score, Glasgow Coma Scale score, complications, and Coumadin use.

Conclusions:

Undertriage poses a substantial risk of mortality for geriatric trauma patients.
Existing trauma triage guidelines require refinement to better identify vulnerable elderly individuals.
Improved tailored triage protocols are essential for enhancing outcomes in geriatric trauma care.