The Effect of Preoperative Tranexamic Acid on Blood Transfusions in Geriatric Hip Fracture Surgery: A Randomized...

To evaluate whether preoperative intravenous tranexamic acid (TXA) reduces postoperative blood transfusion rates in geriatric patients undergoing operative treatment for hip fracture.

Prospective, double-blinded, randomized controlled trial terminated early after interim futility analysis.

Single-center Level I trauma center.

Patients aged ≥65 years who underwent operative treatment for femoral neck (AO/OTA 31-B), intertrochanteric region (AO/OTA 31-A), or subtrochanteric (AO/OTA 32-A/B/C) fractures between June 2019 and June 2022 were included. Procedures included arthroplasty (hemiarthroplasty or total hip arthroplasty) and internal fixation (ORIF) with intramedullary nailing or sliding hip screw fixation. Exclusion criteria were recent thromboembolic events, cancer, hypercoagulable disorders, or TXA allergy.

The primary outcome was postoperative transfusion. Secondary outcomes included hospital length of stay, 30-day readmission, and 90-day complications and mortality. Statistical comparisons were performed using odds ratios, chi-squared, and t-tests, with significance thresholds adjusted by O'Brien-Fleming criteria.

A total of 283 patients were analyzed {TXA: 146 [mean age 84 (range 65-100), 71.9% female; placebo: 137 [mean age 83.1 (range 65-100), 77.2% female]}. Baseline characteristics, including body mass index and procedure type, were comparable (all P > 0.05). A total of 229 patients (80.9%) required no postoperative transfusion (TXA 81%; placebo: 81%, P = 0.97). No significant differences were observed in 30-day readmission ( P = 0.729), 90-day complications ( P = 0.183), hospital length of stay ( P = 0.783), or 90-day mortality ( P = 0.655). Subgroup analysis revealed higher transfusion rates in ORIF versus arthroplasty (ORIF 25%, arthroplasty 8%, P < 0.05), although no difference between TXA and placebo within subgroups ( P = 0.38).

Preoperative TXA was not associated with reduced transfusion requirements in geriatric hip fracture surgery. No significant differences were observed in complications, mortality, or hospital stay. Surgical procedure may influence transfusion risk more than TXA use.

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.