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Related Concept Videos

The Endocrine System01:29

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that every...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
The Pineal Gland01:02

The Pineal Gland

The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
The Pituitary Gland01:17

The Pituitary Gland

The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Published on: January 17, 2018

Sellar meningiomas: an endocrinologic perspective.

Matheni Sathananthan1, Airani Sathananthan, Bernd W Scheithauer

  • 1Department of Endocrinology, Metabolism and Nutrition, 200 First Street SW, Rochester, MN 55905, USA.

Pituitary
|May 31, 2012
PubMed
Summary
This summary is machine-generated.

Sellar meningiomas present with visual issues and often lead to pituitary hormonal problems. Surgical treatment has a high rate of complications and recurrence, necessitating long-term patient follow-up.

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Last Updated: May 21, 2026

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Area of Science:

  • Neurosurgery
  • Endocrinology
  • Oncology

Background:

  • Sellar meningiomas are tumors originating in the sellar region, often impacting vision and endocrine function.
  • Surgical management of these tumors presents significant technical challenges and potential for complications.

Purpose of the Study:

  • To review clinical manifestations and surgical outcomes of intrasellar meningiomas.
  • To identify long-term sequelae and the need for further interventions.

Main Methods:

  • Retrospective chart and pathology review of 17 patients with intrasellar meningiomas.
  • Data abstraction included presentation, endocrine status, surgical approach, pathology, outcomes, and adjunctive treatments.

Main Results:

  • The majority of patients presented with visual disturbances.
  • All tumors were World Health Organization (WHO) grade I.
  • Surgical cure was achieved in 53% after initial surgery, with high rates of postsurgical hypopituitarism.

Conclusions:

  • Sellar meningiomas are challenging tumors associated with high risks of visual and pituitary hormonal dysfunction.
  • Persistent disease and the need for further surgical or radiation treatment are common.
  • Long-term follow-up is crucial for monitoring recurrence and new hormonal insufficiencies.