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Updated: May 21, 2026
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Published on: October 14, 2022
[Indications and surgical outcomes of amniotic membrane transplantation]
Tomoyuki Hino1, Chie Sotozono, Tsutomu Inatomi
1Department of Ophthalmology, Kyoto Prefectural University of Medicine, japan.
Purpose:
To evaluate the indications and surgical outcomes of amniotic membrane transplantation (AMT) for ocular-surface disease.
Subjects And Methods:
This study involved 304 AMTs performed at Kyoto Prefectural University of Medicine between April 1998 and March 2008. Preoperative diagnoses, clinical features, surgical procedures and postoperative outcomes were analyzed retrospectively.
Results:
Of 304 cases, 145 cases had a pterygium (48 primary, 82 recurrent, and 15 pseudo-pterygium). The recurrence rate at one year was 6.1% among the 99 cases of pterygium followed for at least one year postoperatively. Ninety-three cases had severe ocular surface diseases including ocular pemphigoid (30), chemical or thermal burn (29), Stevens-Johnson syndrome (23), and others (11) AMT and epithelial transplantation was combined in 64 cases, and successful ocular-surface reconstruction was obtained in 88 cases (94.6%). Neoplasia was observed in 22 cases (12 benign, 10 malignant). The ocular-surface was successfully reconstructed in all cases by AMT combined with complete tumor resection. Other preoperative diagnoses included persistent epithelial defects (PED) (15), conjunctival chalasis (12) and uncontrollable glaucoma (11). No cases experienced any AMT-related complication.
Conclusions:
AMT proved effective for preventing the recurrence of pterygium and for ocular-surface reconstruction in patients with severe ocular-surface disease or ocular-surface neoplasia.
Insights
Amniotic membrane transplantation (AMT) effectively treats pterygium recurrence and reconstructs the ocular surface for severe diseases and neoplasia, with no complications. This study evaluated 304 AMTs for various ocular conditions.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Tissue Engineering
Context:
- Ocular surface diseases pose significant challenges to vision and require effective treatment strategies.
- Pterygium, severe ocular surface diseases, and ocular surface neoplasia are common indications for surgical intervention.
- Amniotic membrane transplantation (AMT) is a recognized therapeutic option for various ocular surface conditions.
Purpose:
- To evaluate the indications and surgical outcomes of amniotic membrane transplantation (AMT) for ocular-surface disease.
- To assess the efficacy of AMT in managing pterygium recurrence.
- To determine the success rate of AMT in ocular-surface reconstruction for severe diseases and neoplasia.
Summary:
- This retrospective study analyzed 304 amniotic membrane transplantations (AMTs) performed between 1998 and 2008.
- AMT demonstrated a 6.1% recurrence rate for pterygium after one year and achieved successful ocular surface reconstruction in 94.6% of severe disease cases.
- Successful reconstruction was also achieved in all ocular surface neoplasia cases treated with AMT and tumor resection; no AMT-related complications were reported.
Impact:
- Amniotic membrane transplantation (AMT) is a safe and effective treatment for pterygium recurrence.
- AMT facilitates successful ocular surface reconstruction in severe ocular surface diseases and neoplasia.
- The findings support AMT as a valuable therapeutic option in ophthalmology for complex ocular surface conditions.
