Related Experiment Video
Updated: May 21, 2026
10:03
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Mean platelet volume: an important predictor of coronary collateral development
Meltem Refiker Ege1, Savas Acıkgoz, Ali Zorlu
1Kavaklidere Umut Hospital, Clinic of Cardiology, Ankara, Turkey. drmeltemege@yahoo.com.tr
Platelets
|June 1, 2012
Summary
Mean platelet volume (MPV) is a simple predictor of inadequate coronary collateral development (CCD) in patients with coronary artery disease (CAD). Higher MPV levels indicate poorer collateral circulation, offering a cost-effective tool for risk assessment.
Area of Science:
- Cardiology
- Vascular Biology
- Biomarkers
Background:
- Coronary artery disease (CAD) triggers the development of collateral circulation, which is crucial for mitigating infarct size and improving outcomes.
- Significant patient-to-patient variability exists in coronary collateral development (CCD), necessitating reliable predictors of its extent.
Purpose of the Study:
- To investigate the association between mean platelet volume (MPV), a marker of platelet activation, and the degree of coronary collateral circulation in patients with significant CAD.
Main Methods:
- A study included 210 patients undergoing coronary angiography with stenosis ≥50%.
- MPV levels were analyzed from blood samples, and collateral vessels were graded using the Rentrop classification.
- Statistical analyses, including univariate and multivariate logistic regression, were performed to identify predictors of poor CCD.
Main Results:
- 150 out of 210 patients exhibited inadequate CCD.
- Patients with inadequate CCD had significantly higher MPV levels (11.3 ± 1.0 fl vs. 9.5 ± 1.5 fl) and lower Gensini scores.
- MPV and Gensini score were identified as independent predictors of impaired CCD in multivariate analysis.
Conclusions:
- Mean platelet volume (MPV) is a simple, cost-effective, and valuable tool for predicting inadequate coronary collateral development in patients with significant CAD.
- An MPV cut-off value of >9.6 fl demonstrated high sensitivity (96%) and positive predictive value (84.7%) for identifying inadequate CCD.
Related Concept Videos
01:22Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:18Structure and Function of Platelets
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
01:26Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...