Related Experiment Video

Updated: Feb 13, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.9K

Incidence and clinical implications of aortic root thrombosis in LVAD patients: A single-center experience

Mehmet Karahan1, Sinan Sabit Kocabeyoğlu1, Doğan Emre Sert1

  • 1Clinic of Cardiovascular Surgery, Ankara Bilkent City Hospital, Ankara, Türkiye.

Turk Gogus Kalp Damar Cerrahisi Dergisi
|February 12, 2026
PubMed

Insights

Aortic root thrombosis (ART) in patients with left ventricular assist devices (LVADs) may be under-recognized. However, this study found no significant impact of ART on mortality or major adverse events in LVAD patients.

Area of Science:

  • Cardiovascular Medicine
  • Medical Devices
  • Thrombosis Research

Background:

  • Aortic root thrombosis (ART) is a recognized complication in patients with left ventricular assist devices (LVADs).
  • Understanding the clinical outcomes associated with ART is crucial for managing LVAD patients.
  • ART may be under-diagnosed, potentially leading to adverse cardiac and end-organ effects.

Purpose of the Study:

  • To evaluate the clinical outcomes of patients who develop aortic root thrombosis (ART) after receiving a left ventricular assist device (LVAD).
  • To determine the association between ART and adverse events in the LVAD population.

Main Methods:

  • Retrospective analysis of adult LVAD patients implanted between January 2020 and March 2022.
  • Comparison of pre-operative data and post-discharge composite outcomes between patients with and without ART.
  • Composite outcomes included cerebrovascular events, pump thrombosis, myocardial infarction, embolic events, bleeding, right ventricular failure, and mortality.

Main Results:

  • Of 44 LVAD patients, 20 (45%) developed ART post-discharge, with thrombosis occurring at a median of 59 days.
  • The primary site of thrombosis was the non-coronary cusp in 50% of ART cases.
  • No significant differences were observed in composite outcomes (p=0.276), mortality (p=0.814), bleeding (p=0.808), or RV failure (p=0.197) between groups.

Conclusions:

  • Aortic root thrombosis (ART) is a frequent finding in LVAD patients.
  • Despite its occurrence, ART did not significantly increase mortality or major adverse events in this cohort.
  • Close monitoring and management of LVAD patients are essential, even in the absence of significant ART-related complications.
Abstract

Keywords:
Aortic root thrombosisLVADheart failure

More Related Videos

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience09:51

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

Published on: December 4, 2023

1.7K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.7K

Related Concept Videos

Patient-centered Care01:13

Patient-centered Care

Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.1K
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
354
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.9K
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
568
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
485
Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
12.2K