Related Experiment Video

Updated: May 21, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Strategies for the discovery of anti-aging compounds

Syed Ibrahim Rizvi1, Rashmi Jha

  • 1University of Allahabad, Department of Biochemistry, India. sirizvi@gmail.com

Expert Opinion on Drug Discovery
|June 1, 2012
PubMed
Abstract

Insights

Strategies to combat aging focus on delaying age-related diseases. While extending maximum lifespan remains challenging, interventions promoting a longer, healthier life show promise.

Area of Science:

  • Gerontology and anti-aging research.
  • Biomedical science and molecular biology.

Background:

  • Global life expectancy is increasing, leading to a larger elderly population.
  • Age-related diseases are rising, highlighting the need for anti-aging strategies.
  • Anti-aging research aims to prevent or delay age-associated alterations and illnesses.

Purpose of the Study:

  • To review current anti-aging strategies and interventions.
  • To evaluate the efficacy of various anti-aging approaches.

Main Methods:

  • Review of dietary antioxidant supplementation (polyphenols, vitamins E & C, lipoic acid, acetyl carnitine, carnosine, cysteine).
  • Exploration of mammalian target of rapamycin (mTOR) inhibitors and plasma membrane redox system activators.
  • Analysis of hormone supplementation (melatonin, dehydroepiandrosterone, growth hormone, sex hormones).
  • Examination of caloric restriction and its mimetics.

Main Results:

  • Overview of the concepts, applications, and effectiveness of diverse anti-aging interventions.
  • Assessment of the potential of various compounds and therapies in mitigating aging processes.

Conclusions:

  • Extending maximum human lifespan through anti-aging therapies remains an elusive goal despite extensive research.
  • Several interventions show promise for promoting a longer and healthier life span.

More Related Videos

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

Techniques to Induce and Quantify Cellular Senescence06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...