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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
[Loco-regional therapy for liver malignancy in Iceland].
Thorarinn Arni Bjarnason1, Haraldur Bjarnason, Ottar Mar Bergmann
1Laeknadelid Haskola Islands.
Laeknabladid
|June 1, 2012
Summary
Transarterial chemoembolization (TACE) offers palliative treatment for liver tumors, with this study showing manageable complications and positive outcomes, including transplantation downstaging for hepatocellular carcinoma (HCC).
Area of Science:
- Hepatobiliary oncology
- Interventional radiology
- Loco-regional cancer therapy
Background:
- Transarterial chemoembolization (TACE) is a loco-regional therapy for liver tumors, used palliatively or adjunctively.
- TACE can downstage disease, serving as a bridge to liver transplantation.
- This study evaluates TACE outcomes and complications in Iceland.
Purpose of the Study:
- To assess the outcomes of loco-regional therapies for liver tumors in Icelandic patients.
- To determine the frequency and severity of complications associated with these procedures.
Main Methods:
- Retrospective analysis of all Icelandic patients undergoing TACE, transarterial chemotherapy, or bland embolization.
- Study period: May 1, 2007, to March 1, 2011.
- Patient cohort included those with hepatocellular carcinoma (HCC) and carcinoid metastases.
Main Results:
- A total of 26 procedures were performed on 12 patients (9 HCC, 3 carcinoid metastases).
- Mean survival for HCC patients was 15.2 months; carcinoid metastases survival ranged from 61-180 months.
- Minor complications occurred in 6 procedures, with one major complication; no liver failure was reported. One HCC patient received a successful transplant, and three others were downstaged for transplant consideration.
Conclusions:
- Loco-regional therapy for liver tumors in Iceland demonstrated acceptable safety and efficacy.
- TACE facilitated downstaging for liver transplantation in a significant portion of HCC patients.
- The findings support TACE as a valuable treatment option for unresectable liver malignancies.
