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Updated: May 21, 2026

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Published on: August 9, 2024
V/Q SPECT imaging of acute pulmonary embolus - a practical perspective
I J Laurence1, S L Redman, A J G Corrigan
1Radiology Department, Royal United Hospital, Bath, UK.
This article compares scintigraphy and computed tomography pulmonary angiography (CTPA) for diagnosing acute pulmonary embolism (PE). It guides professionals on selecting the best imaging test, including new ventilation-perfusion (V/Q) SPECT techniques.
Area of Science:
- Radiology
- Nuclear Medicine
- Diagnostic Imaging
Background:
- Acute pulmonary embolism (PE) is a critical condition requiring prompt diagnosis.
- Accurate imaging is essential for effective PE management.
- Current diagnostic pathways involve various imaging modalities.
Purpose of the Study:
- To delineate the roles of scintigraphy and CTPA in acute PE diagnosis.
- To provide guidance for selecting the optimal imaging test for patients with suspected PE.
- To share early experiences with ventilation-perfusion (V/Q) single-photon-emission computed tomography (SPECT).
Main Methods:
- Comparison of scintigraphy and CTPA for acute PE investigation.
- Detailed description of V/Q SPECT image acquisition and interpretation.
- Analysis of practical considerations in diverse clinical scenarios.
Main Results:
- Scintigraphy and CTPA offer complementary roles in PE diagnosis.
- V/Q SPECT presents a viable alternative with specific advantages.
- Clinical context is crucial for selecting the most appropriate imaging modality.
Conclusions:
- Both scintigraphy and CTPA are valuable tools for acute PE diagnosis.
- V/Q SPECT is an important addition to the diagnostic armamentarium.
- Tailoring test selection to clinical scenarios optimizes patient care.
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