Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Peroxisomes and Mitochondria01:30

Peroxisomes and Mitochondria

Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within peroxisomes...
Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Cellular Injury I: Introduction01:00

Cellular Injury I: Introduction

Cellular injury occurs when a cell cannot maintain homeostasis or adapt to stressors such as hypoxia, toxins, or trauma. Depending on severity and duration, injury may be reversible, allowing recovery, or irreversible, leading to cell death.General Mechanisms of Cell InjuryAlthough causes vary, most cellular injuries arise from a few key mechanisms that disrupt essential functions and often amplify one another. Cell survival depends on the extent and balance of these disturbances.ATP depletion...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Surgical Mindset: A Systematic Review of Personality Influences on Career Choice in Medicine.

Journal of surgical education·2026
Same author

Medical students' distress during the transition to the endemic phase of COVID-19 in China: The association with temperament traits and attachment styles.

AIMS public health·2025
Same author

Personality dimensions, depression, and eating behavior in individuals seeking bariatric surgery: a cluster analysis.

Frontiers in nutrition·2024
Same author

Improved clinical trial race/ethnicity reporting and updated inclusion profile, 2017-2022: A New Jersey snapshot.

Global epidemiology·2024
Same author

An explorative assessment of ChatGPT as an aid in medical education: Use it with caution.

Medical teacher·2023
Same author

Leveraging the COVID-19 Research Spike to Provide Medical Students with Practical Experience in Data Appraisal and Grant Review.

Medical science educator·2022

Related Experiment Video

Updated: May 21, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Peroxisomes, oxidative stress, and inflammation.

Stanley R Terlecky1, Laura J Terlecky, Courtney R Giordano

  • 1Stanley R Terlecky, Laura J Terlecky, Courtney R Giordano, Department of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201, United States.

World Journal of Biological Chemistry
|June 1, 2012
PubMed
Summary

Peroxisomes manage cellular oxidative balance. Disruptions link peroxisome dysfunction, oxidative stress, and inflammation, contributing to degenerative diseases and offering therapeutic targets.

Keywords:
InflammationOxidative stressPeroxisomes

More Related Videos

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Related Experiment Videos

Last Updated: May 21, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Area of Science:

  • Cell Biology
  • Biochemistry
  • Pathology

Background:

  • Peroxisomes are vital organelles involved in numerous metabolic processes, including the management of reactive oxygen species.
  • Cellular oxidative balance is crucial for tissue homeostasis; its disruption can lead to inflammation and disease.
  • Understanding the interplay between peroxisomes, oxidative stress, and inflammation is key to addressing degenerative conditions.

Purpose of the Study:

  • To review the intricate connections between peroxisome function, oxidative stress, and inflammation.
  • To explore the role of these factors in human health and degenerative diseases.
  • To identify critical dysregulation points and propose potential therapeutic strategies.

Main Methods:

  • Literature review of scientific articles and research data.
  • Analysis of evidence linking peroxisome activity to oxidative stress markers.
  • Examination of inflammatory pathways modulated by peroxisome dysfunction.

Main Results:

  • Peroxisome dysfunction directly contributes to increased oxidative stress within cells.
  • Elevated oxidative stress, often driven by peroxisomal issues, triggers inflammatory responses.
  • These interconnected pathways are implicated in the pathogenesis of various degenerative diseases.

Conclusions:

  • Peroxisome function is a critical determinant of cellular oxidative state and inflammatory tone.
  • Dysregulation in the peroxisome-oxidative stress-inflammation axis is a significant factor in degenerative diseases.
  • Targeting peroxisome pathways may offer novel therapeutic avenues for managing inflammation and disease.