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Published on: December 21, 2019
TRIM22: A Diverse and Dynamic Antiviral Protein.
Clayton J Hattlmann1, Jenna N Kelly, Stephen D Barr
1Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, ON, Canada N6A 5C1.
Molecular Biology International
|June 1, 2012
Summary
The tripartite motif protein 22 (TRIM22) is an ancient protein involved in antiviral defense and cellular processes. This review details TRIM22
Area of Science:
- Molecular Biology
- Virology
- Immunology
Background:
- The tripartite motif (TRIM) protein family is ancient, with TRIM22 found across species.
- TRIM22 exhibits evolutionary dynamics including gene expansion, loss, and positive selection.
- TRIM22 functions in restricting viral replication and is implicated in cellular processes and diseases.
Purpose of the Study:
- To provide a comprehensive summary of the current understanding of TRIM22 structure and function.
- To highlight TRIM22's role in antiviral defense against various viruses.
- To discuss TRIM22's involvement in cellular differentiation, proliferation, cancer, and autoimmune diseases.
Main Methods:
- Literature review and synthesis of existing research on TRIM22.
- Analysis of evolutionary data related to TRIM22.
- Compilation of functional studies demonstrating TRIM22's antiviral and cellular roles.
Main Results:
- TRIM22 is a key antiviral protein restricting replication of viruses like EMCV, HBV, and HIV-1.
- TRIM22 plays roles in cellular differentiation and proliferation.
- TRIM22 is implicated in the pathogenesis of certain cancers and autoimmune diseases.
Conclusions:
- TRIM22 is a multifaceted protein with significant roles in innate immunity and cellular regulation.
- Understanding TRIM22's structure and function is crucial for potential therapeutic applications.
- Further research into TRIM22's evolutionary trajectory and disease associations is warranted.
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