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Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis
Deepshikha Mishra1, Sunita Singh2, Gopeshwar Narayan1
1Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221 005, India.
Molecular Biology International
|December 15, 2016
Summary
The CD10 antigen, a cell surface glycoprotein, plays a complex role in cancer, acting as both a tumor suppressor and promoter. Its deregulated expression is linked to various malignancies and cancer progression.
Area of Science:
- Biochemistry
- Oncology
- Immunology
Background:
- CD10 antigen is a type II transmembrane glycoprotein of the peptidase M13 family.
- Initially identified as a cancer-specific antigen in acute lymphoblastic leukemia, CD10 is widely expressed on various cell types.
- Historically used as a cell surface marker for hematological malignancies.
Approach:
- This review synthesizes current literature on CD10's structural features and functions.
- It examines the evidence for CD10's involvement in cancer development and progression.
- The review discusses the contradictory roles of CD10 in different cancer types.
Key Points:
- CD10 is an ectoenzyme crucial for processes like angiogenesis.
- Its expression levels are frequently deregulated in various cancers.
- CD10 exhibits dual roles, potentially suppressing or promoting tumor progression depending on the cancer context.
Conclusions:
- The precise role of CD10 in tumorigenesis remains incompletely understood.
- Further research is needed to elucidate the mechanisms behind CD10's context-dependent functions in cancer.
- Understanding CD10's multifaceted role is essential for developing targeted cancer therapies.
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