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Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
Published on: March 9, 2019
Surface modification with alginate-derived polymers for stable, protein-repellent, long-circulating gold
Anu Kodiyan1, Eduardo A Silva, Jaeyun Kim
1Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts 02138, USA.
ACS Nano
|June 2, 2012
Summary
Alginate-derived polymers offer enhanced colloidal stability for gold nanoparticles (GNPs), matching polyethylene glycol (PEG) performance. These functionalized polymers show reduced protein interaction and prolonged circulation, presenting a promising alternative for biomedical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Polymer Chemistry
Background:
- Poly(ethylene) glycol (PEG) is a standard for stabilizing gold nanoparticles (GNPs).
- Alternative stabilizers are needed to improve GNP functionality and biocompatibility.
- Alginate-derived polymers offer unique chemical properties for nanoparticle functionalization.
Purpose of the Study:
- To evaluate alginate-derived polymers as stabilizers for gold nanoparticles (GNPs).
- To assess the colloidal stability and biocompatibility of alginate-coupled GNPs.
- To compare alginate-coupled GNPs with traditional PEG-coated and bare citrate-coated GNPs.
Main Methods:
- Synthesis of cysteine-functionalized alginate-derived polymers.
- Coupling of polymers to gold nanoparticles (GNPs).
- In vitro protein interaction studies and in vivo circulation time assessments.
Main Results:
- Alginate-coupled GNPs exhibited enhanced colloidal stability compared to bare citrate-coated GNPs.
- Alginate-coupled GNPs showed minimal protein interaction in vitro, similar to PEG-coated GNPs.
- In vivo studies demonstrated prolonged circulation times for alginate-coupled GNPs.
Conclusions:
- Cysteine-functionalized alginate-derived polymers effectively stabilize gold nanoparticles (GNPs).
- These polymers provide biocompatibility comparable to PEG, with potential for further functionalization.
- Alginate-coupled GNPs represent a viable alternative for advanced nanomedicine applications.
