Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weight-Controllable Biobarcode Probes for Multi-input Breast Cancer Diagnosis.

Nano letters·2026
Same author

Erratum to 'Concept, development and applications of DNA computation' Fundamental Research 6 (2026) 178-183.

Fundamental research·2026
Same author

Size-dependent cryoprotective effects of curcumin nanoparticles on DNA integrity and motility in cryopreserved Angora buck sperm.

Frontiers in veterinary science·2026
Same author

A DNA Origami-Based Cobweb Facilitates Precise and Receptor-Interference Free Modification of Extracellular Vesicle Mimetic for Enhanced Delivery Efficacy.

Journal of the American Chemical Society·2026
Same author

Condensate protein aggregation in ALS/FTD is regulated by GGGGCC-repeat RNA scaffolds.

Nature structural & molecular biology·2026
Same author

Colorimetric Ready-to-Use Microfluidic Chips for Rapid Antibiotic Susceptibility Testing of Methicillin-Resistant <i>Staphylococcus aureus</i> by a Smartphone-Based Analysis.

ACS omega·2026
Same journal

DNAzyme-Enhanced CRISPR/Cas12a Cascade Enables Isothermal, One-Pot RNA Diagnostics.

ACS applied materials & interfaces·2026
Same journal

Continuous π-Conjugation in β-Ketoenamine Covalent Organic Frameworks Boosts Charge Transfer for Selective Photocatalysis.

ACS applied materials & interfaces·2026
Same journal

Scalable Ionogel-Based Thermochromic Smart Windows: Enhanced Solar Regulation, Weatherability, and Processability.

ACS applied materials & interfaces·2026
Same journal

Metal-Organic Framework Monoliths Derived from Emulsion-Templated Foams for Reactive Filtration.

ACS applied materials & interfaces·2026
Same journal

Binary to Quaternary Rare-Earth Phosphates: Compositional Effects on Thermal Properties and CMAS Corrosion Resistance of Environmental Barrier Coatings.

ACS applied materials & interfaces·2026
Same journal

Suture-Free Piezoelectric Band-Aid Membrane for Complex Peripheral Nerve Defects.

ACS applied materials & interfaces·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
07:16

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Aptamer-nanoparticle assembly for logic-based detection.

Mohammed I Shukoor1, Meghan O Altman, Da Han

  • 1Center for Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, University of Florida , Gainesville, Florida 32611-7200, United States.

ACS Applied Materials & Interfaces
|June 2, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces gold nanoparticles that act as logic gates, detecting cancer biomarkers Platelet-Derived Growth Factor (PDGF) and Vascular Endothelial Growth Factor (VEGF) through color and fluorescence changes for improved diagnostics.

More Related Videos

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
03:38

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

Related Experiment Videos

Last Updated: May 21, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
07:16

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition

Published on: February 9, 2024

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
03:38

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Cancer Diagnostics

Background:

  • Proangiogenic factors like PDGF and VEGF are crucial in cancer progression and are key targets for diagnosis and treatment.
  • Existing diagnostic methods may lack the speed, cost-effectiveness, or reliability needed for widespread clinical application.
  • Boolean logic operations offer a framework for complex signal processing in biosensing applications.

Purpose of the Study:

  • To develop a novel sensing system utilizing gold nanoparticles to perform Boolean logic operations.
  • To detect the simultaneous presence of two key cancer-related proteins, PDGF and VEGF.
  • To create a foundation for rapid, affordable, and dependable diagnostic sensors.

Main Methods:

  • Gold nanoparticles were employed to execute Boolean logic operations.
  • The system responded to the presence or absence of target proteins (PDGF and VEGF).
  • Colorimetric changes (red to blue) and fluorescence signals from released dye-labeled aptamer probes were used as outputs.

Main Results:

  • Gold nanoparticles aggregated upon target protein detection, causing a visible color shift from red to blue.
  • The release of dye-labeled aptamer probes resulted in a measurable increase in fluorescence.
  • These distinct outputs enabled the implementation of AND or OR logic gates for simultaneous protein detection.

Conclusions:

  • A gold nanoparticle-based logic gate system successfully detected PDGF and VEGF.
  • The developed system provides simultaneous detection capabilities with distinct visual and fluorescent readouts.
  • This technology holds promise for the development of novel, rapid, cost-effective, and reliable diagnostic sensors for cancer applications.