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C-reactive protein and obstructive sleep apnea syndrome in children

David Gozal1, Leila Kheirandish-Gozal, Rakesh Bhattacharjee

  • 1Department of Pediatrics, Comer Children's Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA. dgozal@uchicago.edu

Frontiers in Bioscience (Elite Edition)
|June 2, 2012
PubMed

Insights

Childhood obesity and obstructive sleep apnea syndrome (OSAS) are linked to inflammation. C-reactive protein (CRP) levels may indicate this increased cardiovascular risk in children.

Area of Science:

  • Pediatric Health
  • Cardiovascular Disease
  • Inflammation Biology

Background:

  • Childhood obesity is a growing epidemic associated with increased cardiovascular and metabolic risks.
  • Obstructive sleep apnea syndrome (OSAS) is common in obese children and shares inflammatory pathways with obesity.
  • Systemic inflammation, marked by C-reactive protein (CRP), is implicated in cardiovascular morbidity and atherogenesis.

Purpose of the Study:

  • To review evidence linking OSAS to systemic inflammation in children.
  • To examine the role of CRP as a biomarker for inflammation in pediatric OSAS and obesity.

Main Methods:

  • Literature review of studies investigating OSAS, obesity, and inflammation in children.
  • Focus on studies utilizing CRP as a marker of systemic inflammation.

Main Results:

  • Obesity prevalence is rising in children, increasing risks for cardiovascular and metabolic diseases.
  • OSAS prevalence is higher in obese children, activating similar inflammatory mechanisms.
  • CRP is a key inflammatory marker associated with cardiovascular risk and may promote atherogenesis.

Conclusions:

  • OSAS and obesity may exacerbate each other's adverse effects through shared inflammatory pathways.
  • CRP is a significant biomarker for systemic inflammation in children with OSAS and obesity.
  • Further research is needed to understand the interplay between OSAS, obesity, and inflammation in pediatric cardiovascular health.

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