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Updated: May 21, 2026
07:30
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Molecular mediators of polymicrobial sepsis
Sandra Wintersteller1, Jens Hahnhaussen, Barbara Kofler
1Department of Pediatrics, Laura Bassi Centre of Expertise, THERAPEP, Research Program for Receptor Biochemistry and Tumor Metabolism, Paracelsus Medical University, 5020 Salzburg, Austria.
Frontiers in Bioscience (Elite Edition)
|June 2, 2012
Summary
Sepsis significantly increases postoperative death. This study reviews animal models and clinical markers to better predict sepsis prognosis and treatment effectiveness, especially for abdominal sepsis.
Area of Science:
- Critical Care Medicine
- Surgical Oncology
- Immunology
Background:
- Sepsis remains a primary driver of postoperative morbidity and mortality.
- Existing immunomodulatory therapies have shown limited success in human clinical trials.
- Reevaluation of current models and development of clinically relevant alternatives are necessary.
Purpose of the Study:
- To provide an overview of common animal models for sepsis.
- To comprehensively review markers for sepsis prediction in both animal and clinical studies.
- To focus on abdominal sepsis, a condition with high mortality rates.
Main Methods:
- Comparison of two animal models simulating intra-abdominal sepsis.
- Review of biochemical and clinical indicators for sepsis prognosis.
- Illustration of predictive clinical parameters for major visceral surgery.
Main Results:
- Identified limitations in current sepsis prediction models.
- Highlighted the high mortality rate (up to 80%) associated with abdominal sepsis post-surgery.
- Presented a comparative analysis of relevant animal models and clinical markers.
Conclusions:
- Animal models require reevaluation for clinical relevance in sepsis research.
- Accurate prediction of sepsis prognosis necessitates a combination of validated markers.
- Improved models and markers are crucial for enhancing patient outcomes in abdominal sepsis.
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