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Synthetic approaches toward sesterterpenoids.

Daniel T Hog1, Robert Webster, Dirk Trauner

  • 1Fakultät für Chemie und Pharmazie, Ludwig-Maximilians-Universität München, and Munich Center for Integrated Protein Science, Butenandtstr. 5-13, 81377 München, Germany.

Natural Product Reports
|June 2, 2012
PubMed
Summary

This review covers the total synthesis of sesterterpenoids, complex bioactive natural products. It highlights synthetic chemistry efforts toward approximately 50 unique sesterterpenoid structures.

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Area of Science:

  • Organic Chemistry
  • Natural Product Synthesis
  • Medicinal Chemistry

Background:

  • Sesterterpenoids are a class of bioactive natural products.
  • These compounds often exhibit complex and unique structural characteristics.
  • Their intricate structures make them appealing targets for synthetic chemists.

Purpose of the Study:

  • To provide a comprehensive overview of the total synthesis of sesterterpenoids.
  • To survey the synthetic strategies and methodologies employed in accessing these molecules.
  • To document the progress in the field by focusing on completed total syntheses.

Main Methods:

  • Literature review of published total syntheses of sesterterpenoids.
  • Focus on studies reporting the complete synthesis of target molecules.
  • Categorization and analysis of synthetic approaches.

Main Results:

  • Compilation of approximately 50 completed total syntheses of sesterterpenoid natural products.
  • Identification of recurring synthetic challenges and innovative solutions.
  • Overview of the diversity of structural motifs accessible through synthesis.

Conclusions:

  • Significant advancements have been made in the total synthesis of sesterterpenoids.
  • Synthetic chemistry plays a crucial role in accessing complex natural products.
  • Continued efforts are expected to yield new synthetic methodologies and access novel sesterterpenoid structures.