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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
IgG-anti-IgA antibodies: an autoimmune finding in patients with psoriasis vulgaris
1Department of Pediatric Immunology, Ege University Medical School, Izmir, Turkey. elif.azarsiz@ege.edu.tr
Aim:
Psoriasis is thought to be an autoimmune disease caused by inappropriate activation of the cellular immune system. In this study, we aimed to search out IgG-anti-IgA antibody levels, serum immunoglobulins and antinuclear antibodies (ANA).
Methods:
The study enrolled 38 psoriasis vulgaris patients and 40 healthy controls.
Results:
Mean IgG-anti-IgA levels were significantly higher in psoriasis patients. The frequency of positive ANA testing was 21.1%; however, there was no correlation between IgG-anti-IgA antibody levels and ANA positivity. Only one patient had low IgA levels without high IgG-anti-IgA concentrations.
Conclusion:
The data about high IgG-anti-IgA antibody levels are noteworthy for a new evidence of autoimmune mechanism.
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