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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Related Experiment Video

Updated: May 21, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Human brown fat and obesity: methodological aspects.

Wouter van Marken Lichtenbelt1

  • 1Department of Human Biology, School for Nutrition and Toxicology and Metabolism, Maastricht University Medical Center Maastricht, Netherlands.

Frontiers in Endocrinology
|June 2, 2012
PubMed
Summary
This summary is machine-generated.

Brown adipose tissue (BAT) generates heat and impacts human energy expenditure, potentially aiding in obesity management. Further research is needed to fully understand human BAT

Keywords:
PET/CTbrown adipose tissuenon-shivering thermogenesisobesity

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Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
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Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

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Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
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Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

Related Experiment Videos

Last Updated: May 21, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
10:30

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

Area of Science:

  • Metabolism and Endocrinology
  • Adipose Tissue Biology

Background:

  • Brown adipose tissue (BAT) is well-characterized in rodents for thermogenesis and energy expenditure regulation.
  • Human BAT functionality in adults has been recently rediscovered, but knowledge remains limited.
  • BAT activation is influenced by cold exposure, diet, and overfeeding.

Purpose of the Study:

  • To review the current understanding of human brown adipose tissue (BAT) and its role in energy expenditure.
  • To explore the potential contribution of BAT to obesity management in humans.
  • To discuss methodological considerations for studying human BAT capacity, recruitment, and function.

Main Methods:

  • Literature review of existing studies on human brown adipose tissue.
  • Analysis of data concerning BAT's role in human energy expenditure.
  • Discussion of techniques for assessing BAT activity and characteristics.

Main Results:

  • Human BAT contributes to increased energy expenditure, offering a potential target for obesity interventions.
  • Methodological challenges exist in accurately measuring human BAT's heat-producing capacity.
  • Understanding BAT recruitment and functionality in humans requires further investigation.

Conclusions:

  • Human brown adipose tissue plays a role in energy balance and may be a therapeutic target for obesity.
  • Standardized methodologies are crucial for advancing research on human BAT.
  • Continued research is essential to fully elucidate the physiological significance of human BAT.