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Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study

R Schutte1, H W Huisman, L Malan

  • 1Hypertension in Africa Research Team, School for Physiology, Nutrition, Consumer Sciences, North-West University, Potchefstroom Campus, Potchefstroom, South Africa. rudolph.schutte@nwu.ac.za

International Journal of Cardiology
|June 5, 2012
PubMed

Insights

In hypertensive African men, higher serum alkaline phosphatase (ALP) levels are linked to poorer arterial health. This finding suggests ALP may indicate increased cardiovascular risk in this population.

Area of Science:

  • Cardiovascular Health
  • Biomarkers
  • Vascular Biology

Background:

  • Vascular calcification, linked to mortality, involves smooth muscle cell transformation.
  • Hypertension and associated mortality are significant concerns in African populations.
  • Alkaline phosphatase (ALP) is a marker of osteoblastic activity.

Purpose of the Study:

  • To investigate the association between serum ALP and arterial structure/function.
  • To explore cardiovascular risk markers in hypertensive African men.

Main Methods:

  • Study included 79 hypertensive African men.
  • Measurements included 24-hour ambulatory blood pressure and carotid intima-media thickness (cIMT).
  • Serum ALP, cIMT, and calculated cross-sectional wall area (CSWA) were analyzed.

Main Results:

  • Elevated 24h systolic blood pressure and pulse pressure correlated positively with ALP.
  • Increased mean cIMT and CSWA showed a positive association with ALP.
  • Associations remained significant after adjusting for covariates and excluding specific health conditions.

Conclusions:

  • Serum alkaline phosphatase is adversely associated with arterial structure and function.
  • Higher ALP levels may indicate increased cardiovascular risk in hypertensive African men.
Abstract

Keywords:
Ambulatory blood pressureCarotid intima–media thicknessHypertensive African menSerum alkaline phosphatase

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