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Updated: May 21, 2026

Supercritical Nitrogen Processing for the Purification of Reactive Porous Materials
Published on: May 15, 2015
Preparative enantioseparations using supercritical fluid chromatography
1Amgen, 360 Binney Street, Cambridge, MA 02142, USA. miller@amgen.com
Abstract:
Chromatographic enantioseparation at the preparative scale is routinely used in pharmaceutical R&D to generate individual enantiomers. Supercritical fluid chromatography (SFC) has many advantages over liquid chromatography for these separations. These advantages include rapid screening of separation conditions at the analytical scale, more rapid preparative separations, higher purification throughputs, decreased solvent consumption and waste generation and higher product concentrations post separation. SFC is a green technique which utilizes significantly less solvent compared to HPLC and can often result in reduced purification costs.
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