Blebbing as a physical force in cancer EMT - parallels with mitosis
Petra Sekyrova1, Joel Östblom, Michael Andäng
1Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles vag 1, SE 171 77 Stockholm, Sweden. petra.sekyrova@ki.se
Abstract:
Epithelial to mesenchymal transition (EMT) during metastasis is initially a two-step process beginning with delamination of cells from the solid tumor followed by acquisition of a migratory phenotype. Several reports indicate that plasma membrane blebbing, associated with cell division, coincides with cell delamination during developmental EMT. This raises a speculative question if blebbing drives EMT in cancer cells in a similar way. Here, we review available data on factors and processes that may support such a connection.
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