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Updated: May 21, 2026
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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
Published on: September 1, 2022
Flexible optitrode for localized light delivery and electrical recording.
1Department of Electrical & Computer Engineering, University of Houston 4800 Calhoun Road, Room N308, Engineering Building 1, Houston, Texas 77204, USA.
Optics Letters
|June 5, 2012
Summary
We developed Optitrode, a flexible probe for simultaneous light delivery and electrical recording. This miniaturized device offers precise control for neuroscience research applications.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Materials Science
Background:
- Integrated neural probes are crucial for advanced neuroscience research.
- Existing devices often lack flexibility or combined optical and electrical capabilities.
Purpose of the Study:
- To introduce Optitrode, a novel miniaturized flexible probe.
- To demonstrate integrated, localized light delivery and electrical recording capabilities.
Main Methods:
- Fabrication using a novel V-groove guided capillary assembly technique.
- Design features an annular light guide surrounding a twisted-wire tetrode.
- Characterization of electrical and optical functions, including performance under bending.
Main Results:
- Successfully fabricated a 5 cm long, 100 μm diameter Optitrode.
- Demonstrated 11% laser power delivery (110 mW) at a 25° bending angle.
- Achieved high-precision coaxial alignment of probe layers.
Conclusions:
- Optitrode offers a promising solution for integrated neural recording and stimulation.
- The device's flexibility and combined functionality are suitable for in vivo neuroscience applications.
- Novel fabrication method enables precise alignment for complex microdevices.
