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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

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Related Experiment Video

Updated: May 21, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

MicroRNAs in renal development.

Jacqueline Ho1, Jordan A Kreidberg

  • 1Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA. jacqueline.ho2@chp.edu

Pediatric Nephrology (Berlin, Germany)
|June 5, 2012
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are small RNAs regulating gene expression, impacting development and disease. This review explores their crucial roles in kidney development and pediatric renal diseases.

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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

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Related Experiment Videos

Last Updated: May 21, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression post-transcriptionally.
  • miRNA-mediated gene regulation is an evolutionarily conserved mechanism crucial for biological processes.
  • Recent research highlights miRNA involvement in kidney development and disease.

Purpose of the Study:

  • To review novel insights into the roles of miRNAs in kidney development.
  • To discuss the implications of miRNAs in pediatric renal disease.

Main Methods:

  • Literature review of recent studies on miRNAs in kidney development and disease.
  • Analysis of miRNA regulatory mechanisms in various cell lineages.
  • Synthesis of findings related to miRNA involvement in kidney pathophysiology.

Main Results:

  • miRNAs play significant roles in cell lineage differentiation during kidney development.
  • Specific miRNAs are implicated in both normal kidney development and the progression of renal diseases.
  • miRNA dysregulation contributes to the pathophysiology of various pediatric renal conditions.

Conclusions:

  • miRNAs are critical regulators of kidney development.
  • Understanding miRNA functions offers potential therapeutic targets for pediatric renal diseases.
  • Further research into miRNA roles can advance the field of nephrology.