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Effervescent granule based proliposomes of ibuprofen
O P Katare1, S P Vyas, V K Dixit
1Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya Sagar, India.
Journal of Microencapsulation
|October 1, 1990
Summary
Effervescent granules were used to create stable ibuprofen proliposomes, achieving nearly 100% encapsulation efficiency. These liposomes demonstrated enhanced anti-inflammatory activity compared to plain ibuprofen.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Nanotechnology
Background:
- Proliposomes offer a stable, dry carrier for liposomes, improving drug formulation.
- Effervescent hydration provides a controlled method for liposome formation.
- Ibuprofen's anti-inflammatory properties can be enhanced through targeted delivery.
Purpose of the Study:
- To prepare proliposomes of ibuprofen using effervescent granules.
- To characterize the resulting liposomes, including size, distribution, and encapsulation efficiency.
- To evaluate the in vivo anti-inflammatory activity of ibuprofen-loaded liposomes.
Main Methods:
- Proliposomes prepared using effervescent granules containing phospholipids, soyabean lecithin, stearylamine, and cholesterol.
- Liposome hydration under effervescence generated by carbon dioxide gas.
- In vivo anti-inflammatory activity assessed using the carrageenan-induced paw edema test.
Main Results:
- Uniformly sized liposomes with narrow size distribution were obtained.
- Encapsulation efficiency approached 100%.
- Liposomes exhibited enhanced anti-inflammatory activity compared to plain ibuprofen post-intravenous administration.
Conclusions:
- Effervescent granules provide an effective method for preparing stable ibuprofen proliposomes.
- The carbon dioxide atmosphere during hydration prevents phospholipid oxidation.
- Liposomal ibuprofen demonstrates superior anti-inflammatory efficacy, suggesting improved drug delivery.