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Related Experiment Video

Updated: May 21, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Dextran sodium sulphate colitis mouse model: traps and tricks.

Martina Perše1, Anton Cerar

  • 1Institute of Pathology, Medical Experimental Centre, Medical Faculty, University of Ljubljana, Zaloška 4, 1105 Ljubljana, Slovenia. martina.perse@mf.uni-lj.si

Journal of Biomedicine & Biotechnology
|June 6, 2012
PubMed
Summary

The dextran sulphate sodium (DSS) model offers a simple method for studying inflammatory bowel disease (IBD) in animals. However, researchers must be aware of factors that can influence DSS-induced colitis results.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Inflammatory bowel disease (IBD) is a complex condition with unknown causes.
  • Numerous animal models exist to study IBD pathogenesis and treatments.
  • The dextran sulphate sodium (DSS)-induced colitis model is widely used due to its simplicity.

Purpose of the Study:

  • To highlight the advantages of the DSS-induced colitis model for IBD research.
  • To identify potential pitfalls and influencing factors in the DSS model.
  • To provide guidance for optimizing the use of the DSS model in experimental settings.

Main Methods:

  • Review and analysis of existing literature on DSS-induced colitis.
  • Discussion of the similarities between DSS-induced colitis and human IBD.

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Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
12:37

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

Published on: September 11, 2012

Related Experiment Videos

Last Updated: May 21, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Published on: January 19, 2010

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
12:37

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

Published on: September 11, 2012

  • Identification of key variables affecting susceptibility and outcomes in the DSS model.

    • Main Results:

    • The DSS model offers a straightforward approach to mimicking aspects of human IBD.
    • Various experimental factors can significantly alter the severity and presentation of DSS-induced colitis.
    • Understanding these factors is crucial for reproducible and reliable research outcomes.

    Conclusions:

    • The DSS model is a valuable tool for IBD research, but requires careful consideration of influencing variables.
    • Awareness of potential "traps" in the DSS model is essential for accurate interpretation of results.
    • Further research should focus on standardizing protocols to enhance the reliability of the DSS model.