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[Influence of thyroid function in CPK serum levels]
Josivan Gomes de Lima1, Lúcia Helena Coelho Nóbrega, Maria Lúcia Coelho Nóbrega
1Hospital Universitário Onofre Lopes (HUOL), Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil. josivanlima@gmail.com
Arquivos Brasileiros De Endocrinologia E Metabologia
|June 6, 2012
Summary
Serum creatine phosphokinase (CPK) levels correlate positively with thyroid-stimulating hormone (TSH) and negatively with free thyroxine (FT4). CPK levels are lower in hyperthyroidism and higher in hypothyroidism.
Area of Science:
- Endocrinology
- Clinical Chemistry
Context:
- Thyroid dysfunction, including hyperthyroidism and hypothyroidism, can affect various physiological processes.
- Creatine phosphokinase (CPK) is an enzyme found in muscle, brain, and other tissues, and its serum levels can indicate tissue damage or metabolic changes.
Purpose:
- To investigate the relationship between serum CPK levels and thyroid hormones, specifically TSH and FT4.
- To compare serum CPK levels in patients with hyperthyroidism and hypothyroidism to those in euthyroid states.
Summary:
- A retrospective analysis of 6,230 laboratory results revealed a positive correlation between TSH and CPK (r = 0.065) and a negative correlation between FT4 and CPK (r = -0.091, p < 0.05).
- Patients with hyperthyroidism (9.4%) showed lower median CPK levels (98 U/L), while those with hypothyroidism (8.9%) exhibited higher median CPK levels (114 U/L) compared to euthyroid individuals.
Impact:
- These findings suggest that serum CPK levels can serve as a potential biomarker for assessing thyroid status.
- Understanding these correlations can aid in the diagnosis and management of thyroid disorders.
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