Related Experiment Video
Updated: May 21, 2026
Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
A novel model of distal colon cancer in athymic mice
Denise Gonçalves Priolli1, Ana Margarida Abrantes, Silvia Neves
1Medical School, Sao Francisco University, Bragança Paulista, SP, Brazil. depriolli@terra.com.br
Purpose:
The present a novel adenocarcinoma model in athymic mice.
Methods:
Seven athymic mice were used. Colon diversion and distal fistula were made. Adenocarcinoma cells were inoculated in the submucosa of fistula. Tumor growth was monitored daily. Scintigraphy with 99mTc-MIBI was performed to identify the tumor.
Results:
The model of distal colon cancer is feasible. Tumor detection was possible by both, macroscopically and molecular imaging. All resections demonstrated poorly differentiated tumors. Colon obstruction occurred in one case, similarly to evolution in human tumors of distal colon.
Conclusion:
The proposed model of distal colon cancer is feasible, allows for easy monitoring of tumoral growth by both, macroscopically and molecular imaging, and is suitable for studying the evolution of tumor with implementation of cytotoxic therapy in vivo.
