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Updated: May 21, 2026
08:38
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
[Newer immunosuppressive agents and their place in current practice]
1Klinika nefrologie TC Institutu klinické a experimentální medicíny, Praha.
Casopis Lekaru Ceskych
|June 7, 2012
Summary
The past decade introduced new immunosuppressive drugs and antibodies, primarily for organ transplantation. These agents, including tacrolimus, mycophenolate mofetil, sirolimus, and IL-2 receptor antibodies, offer diverse strategies for immunosuppression and anti-rejection therapy.
Area of Science:
- Immunology
- Pharmacology
- Transplantation Medicine
Background:
- The last decade has seen significant advancements in immunosuppressive therapies.
- Novel drugs and antibodies have expanded treatment options for organ transplantation.
Purpose of the Study:
- To review the expanding arsenal of novel immunosuppressive agents.
- To outline the indications and mechanisms of new immunosuppressants in organ transplantation.
Main Methods:
- Literature review of recent immunosuppressive agents.
- Analysis of drug actions and clinical applications in transplantation.
Main Results:
- Tacrolimus is a mainstay or rescue therapy, similar to cyclosporin A.
- Mycophenolate mofetil replaces azathioprine; sirolimus is used prophylactically.
- Basiliximab and daclizumab are IL-2 receptor antibodies for induction therapy.
Conclusions:
- New immunosuppressive agents offer diverse therapeutic options for organ transplant recipients.
- Specific agents like tacrolimus, mycophenolate mofetil, sirolimus, basiliximab, and daclizumab have defined roles in post-transplant management.
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