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Fluid management for dengue in children

Nguyen Thanh Hung1

  • 1Department of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Viet Nam. hungdhf@hcm.fpt.vn

Paediatrics and International Child Health
|June 7, 2012
PubMed

Insights

Isotonic crystalloid solutions effectively treat most Dengue Shock Syndrome (DSS) patients. For severe cases, medium-molecular-weight colloid solutions offer optimal plasma volume support with fewer adverse events.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Pediatrics

Background:

  • Dengue fever is a global health concern, with Dengue Shock Syndrome (DSS) posing a critical threat.
  • Prompt treatment is vital for DSS, as it can be fatal within 12-24 hours.
  • Intravenous fluid therapy is essential for DSS patients and some non-shocked dengue patients.

Purpose of the Study:

  • To summarize clinical data comparing fluid resuscitation regimens in children with severe dengue.
  • To evaluate the efficacy and safety of different fluid solutions for Dengue Shock Syndrome.

Main Methods:

  • Review of key clinical data on fluid management in severe dengue.
  • Comparison of crystalloid and colloid solutions for plasma volume support.

Main Results:

  • Most Dengue Shock Syndrome patients can be successfully treated with isotonic crystalloid solutions.
  • Colloid solutions may be used in severe cases but carry higher risks.
  • Medium-molecular-weight colloids are optimal if colloids are necessary, balancing efficacy and safety.

Conclusions:

  • Isotonic crystalloids are generally sufficient for treating Dengue Shock Syndrome.
  • Careful selection of colloid solutions is crucial when required, favoring medium-molecular-weight preparations.
  • Further research is needed on early colloid administration and optimal colloid choice for DSS resuscitation.

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