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Updated: May 21, 2026
Denver Papillae Protocol for Objective Analysis of Fungiform Papillae
Published on: June 8, 2015
An evaluation of the Shandon Papspin liquid-based oral test using a novel cytologic scoring system
Amir Afrogheh1, Colleen Anne Wright, Sean Liam Sellars
1Department of Oral Pathology, University of the Western Cape and National Health Laboratory Services, Tygerberg Hospital, Cape Town, South Africa. amir.afrogheh@nhls.ac.za
Objectives:
The aim of this study was to evaluate a cost-effective oral liquid-based cytology screening test, Shandon Papspin (PS).
Study Design:
We compared the diagnostic accuracy of PS with surgical biopsy in 69 patients. Transepithelial cytology specimens were obtained with the use of cervical cytobrushes. Cytology specimens were graded and scored by using a novel oral cytologic grading and scoring system.
Results:
Histologic diagnosis of dysplasia or malignancy was made in 51/69 cases, and cytology identified 49/51 cases, with a sensitivity of 96% and specificity of 100%. The best cutoff value for distinguishing reactive/mildly dysplastic lesions from high grade/invasive squamous cell carcinoma was determined to be a cytologic score of 3, representing a sensitivity of 95% and specificity of 96%.
Conclusions:
PS appears to be an accurate and economical test for detection of high-risk dysplasias and cancers, but the real significance of this method will be its diagnostic accuracy in studies focusing strictly on lesions with a low level of clinical concern.
