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Effect of an herbal compound for treatment of burning mouth syndrome: randomized, controlled, double-blind clinical
Juliana Cassol Spanemberg1, Karen Cherubini, Maria Antonia Zancanaro de Figueiredo
1School of Dentistry, Oral Medicine Division, São Lucas Hospital, Pontifical Catholical University of Rio Grande do Sul, Porto Alegre, Brazil. jcs.odonto@yahoo.com.br
Objective:
This randomized, double-blind, placebo-controlled clinical study aimed at evaluating the effect of the systemic use of an herbal compound (Catuama) on the symptoms of burning mouth syndrome (BMS).
Study Design:
Seventy-two patients with BMS were randomly allocated into test (n = 38) and control (n = 34) groups. Patients were instructed to take 2 capsules each day for 8 weeks. They were reassessed at 4, 8, and 12 weeks after treatment onset using a faces scale (FS) and a visual numeric scale (VNS).
Results:
Although both groups demonstrated a reduction in symptoms, the improvement observed in the test group was significantly greater than in the control group after 4 (FS: P = .010) and 8 (VNS: P = .03; FS: P < .001) weeks of treatment. This significant reduction was maintained 12 weeks after treatment onset (FS, VNS: P = .001).
Conclusions:
The systemic administration of Catuama reduces the symptoms of BMS and may be a novel therapeutic strategy for the treatment of this disease.
