Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural variations in small RNA origin loci generate circuit diversity underlying temperature acclimation in <i><i>Caenorhabditis elegans</i></i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Protein Homeostasis Screen Identifies CK2 Inhibition as a Driver of CARD9 Depletion.

ACS chemical biology·2026
Same author

Smart Nanostructures in Oncology: Revolutionising Drug Delivery and Diagnostics.

Current pharmaceutical design·2026
Same author

Microbe-dependent inter-organ communication regulates germline stem cell proliferation in <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2026
Same author

Protocol of the Temporality, Eating and Metabolic health during PreconceptiOn (TEMPO) study in females with overweight and obesity: a prospective observational cohort nested within a preconception lifestyle intervention program.

Reproductive health·2026
Same author

Triclosan-isatin hybrids as potent anti-proliferative agents inducing S-phase arrest <i>via</i> DNA gyrase inhibition in triple-negative breast cancer.

RSC medicinal chemistry·2026
Same journal

PBX-dependent and -independent Hox programs establish and maintain motor neuron terminal identity.

Development (Cambridge, England)·2026
Same journal

NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity.

Development (Cambridge, England)·2026
Same journal

Cell size control emerges from the vein-dependent coordinated divisions of distinct cell groups in Drosophila wing.

Development (Cambridge, England)·2026
Same journal

The people behind the papers - Kaoru Sugimura.

Development (Cambridge, England)·2026
Same journal

The people behind the papers - Zhainib Amir-Ugokwe and Kristy Red-Horse.

Development (Cambridge, England)·2026
Same journal

In preprints: toward a holistic lineage-tracing map of mammalian embryogenesis.

Development (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Tudor domain proteins in development.

Jun Wei Pek1, Amit Anand, Toshie Kai

  • 1Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604. pek@ciwemb.edu

Development (Cambridge, England)
|June 7, 2012
PubMed
Summary
This summary is machine-generated.

Tudor domain proteins act as adaptors, binding methylated residues to build molecular complexes. These proteins play key roles in development, particularly in RNA pathways, DNA repair, and chromatin regulation.

More Related Videos

Analysis of Transforming Growth Factor &#223; Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos
06:57

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Published on: July 21, 2021

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling
06:55

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling

Published on: May 26, 2011

Related Experiment Videos

Last Updated: May 21, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Analysis of Transforming Growth Factor &#223; Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos
06:57

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Published on: July 21, 2021

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling
06:55

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling

Published on: May 26, 2011

Area of Science:

  • Molecular biology
  • Developmental biology
  • Epigenetics

Background:

  • Tudor domain proteins are crucial molecular adaptors.
  • They bind methylated arginine and lysine residues on substrates.
  • This binding facilitates the assembly of macromolecular complexes.

Purpose of the Study:

  • To review the diverse roles of Tudor domain proteins in biological processes.
  • To highlight their significance during organismal development.
  • To discuss their involvement in RNA metabolism and DNA damage response.

Main Methods:

  • Literature review and synthesis of existing research on Tudor domain proteins.
  • Analysis of studies focusing on developmental roles.
  • Examination of data related to RNA metabolism and chromatin modification.

Main Results:

  • Tudor domain proteins are implicated in various cellular functions beyond their adaptor role.
  • Their function is particularly critical in the Piwi-interacting RNA (piRNA) pathway during development.
  • Emerging evidence links them to broader RNA metabolism, DNA damage response, and chromatin modification.

Conclusions:

  • Tudor domain proteins are versatile regulators with essential functions in development and cellular maintenance.
  • Their roles extend across multiple pathways, including gene regulation and genome stability.
  • Further research is warranted to fully elucidate their complex mechanisms and therapeutic potential.