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Related Experiment Video

Updated: May 21, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

Long-term urinary bladder function following unilateral refluxing low loop cutaneous ureterostomy.

Dorit E Zilberman¹, Jacob Golomb, Noam D Kitrey

¹Department of Urology, Chaim Sheba Medical Center, Tel-Ha'shomer, 52621 Ramat-Gan, Israel.

Korean Journal of Urology

|June 7, 2012

Summary

Unilateral low loop cutaneous ureterostomy (LLCU) effectively preserves long-term urinary bladder function in newborns with massively dilated and refluxing ureters. This temporary urinary diversion method shows promising results for maintaining bladder health.

Keywords:

Ureteral reflux Ureterostomy Urinary bladder function

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Vessel-sparing Excision and Primary Anastomosis

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A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

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Published on: July 18, 2025

Vessel-sparing Excision and Primary Anastomosis

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

Area of Science:

Pediatric Urology
Surgical Management of Reflux
Urinary Diversion Techniques

Background:

Massively dilated and refluxing ureters in newborns often necessitate urinary diversion.
Unilateral low loop cutaneous ureterostomy (LLCU) has been a preferred temporary diversion method.
The long-term impact of LLCU on bladder function remains an area of investigation.

Purpose of the Study:

To evaluate the long-term effectiveness of unilateral LLCU in preserving urinary bladder function.
To assess the functional outcomes of the urinary bladder after temporary LLCU in neonates.
To determine if LLCU impacts lower urinary tract symptoms and bladder capacity.

Main Methods:

Retrospective chart review of patients undergoing temporary unilateral LLCU as newborns for massive vesico-ureteric reflux.
Inclusion of patients with a minimum follow-up period.
Assessment of bladder function through patient interviews, uroflowmetry, and post-void residual (PVR) measurements.

Main Results:

Eight patients were analyzed from a cohort of 24, with a median follow-up of 12.5 years.
The urinary bladders demonstrated normal contour, capacity, and minimal PVRs in most cases.
No patients required augmentation cystoplasty; one experienced urinary leakage, and a few had minimal lower urinary tract symptoms (LUTS).

Conclusions:

Unilateral refluxing LLCU is an effective temporary urinary diversion strategy.
LLCU demonstrates the ability to preserve urinary bladder function in the long term.
Further research with larger cohorts is recommended to validate these findings.