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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma

Antonella Fogliata¹, Marta Scorsetti, Piera Navarria

¹Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland. afc@iosi.ch

Acta Oncologica (Stockholm, Sweden)

|June 8, 2012

Summary

Volumetric modulated arc therapy (VMAT) and proton beams offer effective soft-tissue sarcoma treatment. Proton therapy demonstrated superior dose homogeneity and reduced low-dose exposure to bone tissue.

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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Area of Science:

Radiation oncology
Medical physics

Background:

Soft-tissue sarcoma treatment requires precise radiation delivery.
Balancing target coverage with bone sparing is crucial.

Purpose of the Study:

To compare volumetric modulated arc therapy (VMAT) with proton beams for soft-tissue sarcoma.
To assess the potential for simultaneous target coverage and bone sparing.

Main Methods:

Ten leg soft-tissue sarcoma patients were studied.
Dose prescribed: 66.5 Gy to PTV, bone max dose <50 Gy.
Compared RapidArc (photons) and intensity-modulated proton therapy (IMPT).

Main Results:

Both VMAT and proton plans met target coverage and bone sparing criteria.
Proton plans showed significantly higher PTV dose homogeneity.
Protons minimized bone volumes receiving medium/low doses.

Conclusions:

Both VMAT and proton therapy achieve high plan quality for soft-tissue sarcoma.
Proton therapy offers advantages in dose distribution for bone sparing.