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Updated: May 21, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
Atopic dermatitis: a candidate for disease-modifying strategy
1Department of Dermatology and Allergy, University of Bonn, Bonn, Germany. thomas.bieber@ukb.uni-bonn.de
Abstract:
The concept of disease modification has been introduced to define the therapeutic strategies aimed to break, stop, or reverse the natural course of a chronic invalidating disease. This strategy is tightly related to the biomarker-based stratification of affected patients using genetic and other biological markers. With regard to the progress in understanding the genetic background of atopic dermatitis (AD), its natural history and its pivotal role in the emergence of allergic asthma, the time is mature to foster the research field of biomarkers in AD and to consider the elaboration of disease-modifying strategies in the management of AD with the goal to stop or even reverse the atopic march.
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