Related Experiment Video
Updated: May 21, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
Published on: September 7, 2021
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience
Takahiko Umahara1, Toshiki Uchihara, Toshihiko Iwamoto
1Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
Abstract:
This review focuses on the possible relevance of 14-3-3 proteins in geriatric neuroscience. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm. These proteins regulate intracellular signal cascades for differentiation, development, growth, apoptosis and survival. Seven isoforms have so far been identified in mammals. The binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. First, we provide a brief summary of the molecular structure and multiple functions of 14-3-3 proteins. Second, we review the involvement of 14-3-3 proteins in common diseases of geriatric neurology, such as Alzheimer's disease and tauopathies, Parkinson's disease and α-synucleinopathies, Huntington's disease and polyglutamine diseases, Creutzfeldt-Jakob disease and prion diseases, cerebral infarction, and atherosclerosis. Finally, we discuss the immunohistochemical localization of 14-3-3 proteins and its isoforms during the postnatal development of rat brains as a basis for understanding adult neurogenesis. The elucidation of the isoform-dependent functions of 14-3-3 proteins with regard to brain development might be promising for the future development of novel therapeutic interventions for common diseases of geriatric neurology.
Related Concept Videos
Pharmacodynamics in Geriatric Patients: Effects of Age
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Protein Folding Quality Check in the RER

