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Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Quantitative Aspects of Drug-Receptor Interaction01:30

Quantitative Aspects of Drug-Receptor Interaction

The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower Kd...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2, D-Pen5]-enkephalin or DPDPE for...

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Related Experiment Video

Updated: May 21, 2026

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
14:34

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

Published on: April 3, 2026

How to use the IUPHAR receptor database to navigate pharmacological data.

Chidochangu P Mpamhanga1, Joanna L Sharman, Anthony J Harmar

  • 1University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.

Methods in Molecular Biology (Clifton, N.J.)
|June 8, 2012
PubMed
Summary

The International Union of Basic and Clinical Pharmacology Database (IUPHAR-DB) offers expert-curated data on receptors and ion channels. This resource aids scientists in tracking experimental techniques and ligand information for interdisciplinary research.

Related Experiment Videos

Last Updated: May 21, 2026

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
14:34

A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

Published on: April 3, 2026

Area of Science:

  • Pharmacology
  • Bioinformatics
  • Molecular Biology

Background:

  • Modern scientific research is increasingly data-intensive and interdisciplinary.
  • Keeping abreast of experimental techniques and tools reported in scientific literature presents a significant challenge for researchers.
  • A centralized, reliable resource is needed to consolidate pharmacological information.

Purpose of the Study:

  • To introduce the International Union of Basic and Clinical Pharmacology Database (IUPHAR-DB) as a solution for accessing curated pharmacological data.
  • To highlight the database's role in disseminating nomenclature recommendations from the IUPHAR Nomenclature Committee (NC-IUPHAR).
  • To demonstrate how IUPHAR-DB facilitates the documentation of receptor/ion channel properties and associated ligands.

Main Methods:

  • Expert curation of information sourced directly from primary scientific literature.
  • Development of a user-friendly online platform for data accessibility.
  • Integration of nomenclature recommendations and experimental data.

Main Results:

  • IUPHAR-DB provides a comprehensive, expertly curated online repository of pharmacological information.
  • The database facilitates access to nomenclature recommendations for receptors and ion channels.
  • It documents receptor properties and ligands crucial for characterization.

Conclusions:

  • IUPHAR-DB addresses the need for accessible, curated scientific data in pharmacology.
  • The database serves as a vital tool for researchers navigating complex, interdisciplinary studies.
  • IUPHAR-DB is freely available online, promoting wider scientific collaboration and knowledge dissemination.