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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors.

Stephen P H Alexander1, Doriano Fabbro2, Eamonn Kelly3

  • 1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

British Journal of Pharmacology
|November 12, 2019
PubMed
Summary

The Concise Guide to Pharmacology 2019/20 offers a comprehensive overview of 1800 human drug targets, detailing selective pharmacology and providing links to an extensive online knowledgebase for researchers.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Biomedical Sciences

Background:

  • The Concise Guide to Pharmacology is a biennial publication.
  • It serves as a critical resource for understanding human drug targets.

Purpose of the Study:

  • To provide concise overviews of nearly 1800 human drug targets.
  • To emphasize selective pharmacology and link to a detailed online knowledgebase.
  • To offer a permanent, citable record of drug target information.

Main Methods:

  • Compilation of data on human drug targets.
  • Categorization into six major target classes: catalytic receptors, G protein-coupled receptors, ion channels, nuclear hormone receptors, enzymes, and transporters.
  • Inclusion of nomenclature guidance, pharmacological tools, references, and further reading suggestions.

Main Results:

  • The 2019/20 edition covers approximately 1800 human drug targets.
  • Information is presented in a landscape format for easy comparison.
  • Official IUPHAR (International Union of Basic and Clinical Pharmacology) classification and nomenclature are provided where applicable.

Conclusions:

  • The Concise Guide to Pharmacology 2019/20 is an essential, up-to-date reference for pharmacologists and drug developers.
  • It bridges the gap between concise summaries and extensive online databases.
  • The publication ensures a stable, citable record of pharmacological knowledge.