AntibioticDB: An Updated and Improved Open-Access Database for the Antibacterial Research and Development Community.

Area of Science:

• * Pharmacology and Medicinal Chemistry
• * Cheminformatics and Bioinformatics

Background:

• * AntibioticDB is a freely accessible database of antibacterial agents, established in 2017 and led by the Global Antibiotic Research & Development Partnership (GARDP) since 2021.
• * The database aims to support and accelerate the research and development of novel antibacterial therapeutics.
• * Previous versions required enhancements to better serve the scientific community.

Purpose of the Study:

• * To announce and describe the latest release of the AntibioticDB database.
• * To highlight significant expansions, updated functionalities, and improved data integration.
• * To emphasize the database's role as a comprehensive global resource for antibacterial agents.

Main Methods:

• * Redesigned web portal with enhanced user functionality.
• * Reciprocal integration with the IUPHAR/BPS Guide to Pharmacology.
• * Incorporation of standard chemical identifiers (SMILES, InChI, InChI Key) and 2D structure images.
• * Harmonization of terminology for optimized database searching.
• * Continuous literature mining and data curation for new antibacterial compounds.

Main Results:

• * AntibioticDB now features over 3,500 entries, significantly expanded from previous versions.
• * A substantial increase in historical natural product antibiotics has been incorporated.
• * Enhanced data capture includes chemical structures and identifiers, improving data utility.
• * The database is continuously updated with newly reported antibacterial compounds.

Conclusions:

• * The updated AntibioticDB is a more comprehensive and user-friendly resource for researchers.
• * Its expanded content, particularly natural product antibiotics, and improved data integration facilitate drug discovery.
• * AntibioticDB solidifies its position as the most complete global resource for antibacterial agents.