Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Diabetes Insipidus I: Introduction01:29

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase-Dependent MoS<sub>2</sub> Nanosheets-Embedded Urinary Catheter for Advanced Photothermal Sterilization.

International journal of molecular sciences·2026
Same author

Early and Prolonged Cortical Electrical Stimulation Preserves Motor Functions and Nigrostriatal Dopaminergic Neurons in the MitoPark Model of Parkinson's Disease.

Journal of integrative neuroscience·2026
Same author

Effect of <i>Bifidobacterium longum</i> on cognition and microbiota in post-stroke patients: a single-blinded, controlled trial.

International journal of medical sciences·2026
Same author

Inertial Trajectory Estimation Using Low-Cost Inertial Measurement Units and Edge Computing.

IEEE journal of biomedical and health informatics·2026
Same author

Comparison of the performance of a Three-Dimensional Body Scanner and radiography in evaluating adult scoliosis.

PeerJ·2026
Same author

Therapeutic Effects of Noninvasive Technology Modalities on Lower-Limb Motor Function in Spinal Cord Injury: A Systematic Review.

Archives of rehabilitation research and clinical translation·2026

Related Experiment Video

Updated: May 21, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Pudendal neuromodulation improves voiding efficiency in diabetic rats.

Shih-Ching Chen1, Chien-Hung Lai, Wen-Jia Fan

  • 1Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Neurourology and Urodynamics
|June 8, 2012
PubMed
Summary

Electrical stimulation of the pudendal nerve improved bladder emptying in diabetic rats with cystopathy. This approach shows promise for treating diabetic patients experiencing bladder voiding dysfunction.

More Related Videos

Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
07:42

Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents

Published on: April 25, 2017

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Related Experiment Videos

Last Updated: May 21, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
07:42

Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents

Published on: April 25, 2017

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Area of Science:

  • Neuroscience
  • Urology
  • Diabetology

Background:

  • Diabetic cystopathy causes bladder voiding dysfunction, often resistant to conventional treatments.
  • Understanding the neural mechanisms of bladder control is crucial for developing effective therapies.

Purpose of the Study:

  • To investigate the efficacy of electrical stimulation (ES) of the pudendal nerve's sensory branch in improving bladder emptying in a diabetic rat model.
  • To determine if ES can activate an augmenting reflex to restore bladder function.

Main Methods:

  • Diabetes was induced in rats using streptozotocin.
  • Electrical stimulation of the pudendal nerve's sensory branch was applied at varying intensities.
  • Bladder emptying efficiency was measured in rats at 8 and 18 weeks post-diabetes induction.

Main Results:

  • Diabetic rats showed significantly reduced voiding efficiency (VE) compared to controls.
  • Low-intensity ES had limited effect, but higher intensities (0.1-0.3 mA) increased VE in both 8- and 18-week diabetic rats.
  • VE increased to 40-50% with effective ES in diabetic rats.

Conclusions:

  • Pudendal sensory feedback plays a vital role in maintaining efficient bladder emptying.
  • Electrical activation of the pudendal sensory nerve effectively restored voiding function in diabetic cystopathy models.
  • This neurostimulation technique offers a potential therapeutic strategy for diabetic patients with bladder voiding dysfunction.