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Updated: May 21, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
The emerging role of PEDF in stem cell biology
Mina Elahy1, Swati Baindur-Hudson, Crispin R Dass
1Department of Biomedical and Health Sciences, Victoria University, St Albans, VIC 3021, Australia.
Abstract:
Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency.
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